Gamma-secretase modulator 6
Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. gamma-secretase modulator 6 inhibits Aβ42 secretion in HEK cell line stably expressing APP (Aβ amyloid precursor protein) (pIC50: 8.1) . gamma-secretase modulator 6 can be used for research of Alzheimer's disease[1].
Product Specifications
CAS Number
[1255700-88-9]
UNSPSC
12352005
Target
Amyloid-β; γ-secretase
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
99.68
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(C2=CN(N=C2)C)C=CC(NC3=CC=C(CN(C[C@@H](C4=CC=CC=C4)O5)C)C5=N3)=N1
Molecular Formula
C25H26N6O2
Molecular Weight
442.51
References & Citations
[1]Yvonne Lo-Alfredsson, et al. New compounds modulating gamma-secretase and their use in the treatment of alpha beta related pathologies, such as alzheimer's disease. Patent. WO2010132015
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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