Gamma-secretase modulator 6

Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. gamma-secretase modulator 6 inhibits Aβ42 secretion in HEK cell line stably expressing APP (Aβ amyloid precursor protein) (pIC50: 8.1) . gamma-secretase modulator 6 can be used for research of Alzheimer's disease[1].

Product Specifications

CAS Number

[1255700-88-9]

UNSPSC

12352005

Target

Amyloid-β; γ-secretase

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

99.68

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(C2=CN(N=C2)C)C=CC(NC3=CC=C(CN(C[C@@H](C4=CC=CC=C4)O5)C)C5=N3)=N1

Molecular Formula

C25H26N6O2

Molecular Weight

442.51

References & Citations

[1]Yvonne Lo-Alfredsson, et al. New compounds modulating gamma-secretase and their use in the treatment of alpha beta related pathologies, such as alzheimer's disease. Patent. WO2010132015