P1D-34
P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. P1D-34 also down-regulates Pin1 client proteins such as Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. P1D-34 shows anti-proliferative activities in a panel of acute myeloid leukemia (AML) cell lines. P1D-34 induces cell DNA damage and apoptosis by releasing ROS generation. Pink: PIN1 ligand , Blue: CRBN ligand (HY-14658), Black: Linker (HY-W014883).
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; CDK; c-Myc; PIN1; PROTACs; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(NCC(C)(C)CN([C@H](CC1)CS1(=O)=O)C(CCl)=O)CCC(NCCCCCCCCCCCCNC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)=O
Molecular Formula
C40H59ClN6O9S
Molecular Weight
835.45
References & Citations
[1]Shi Y, et al. Discovery of potent PROTAC degraders of Pin1 for the treatment of acute myeloid leukemia. Chem Sci. 2024 Feb 28;15 (13) :5027-5035.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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