(Rac) -P1D-34

PROTAC PIN1 degrader-2 (1) is a PROTAC-based PIN1 degrader (Pink: PIN1 ligand HY-171442, Blue: cereblon ligand Thalidomide (HY-14658), Black: linker HY-W014883) . PROTAC PIN1 degrader-2 (1) possesses anti-cancer activity, with IC50 values of 2248 nM (MV-4-11 cells), 3984 nM (MOLM-13), 3925 nM (HL-60), 3925 nM (HL-60), 3925 nM (HL-60), 3925 nM (HL-60) and 3925 nM (HL-60) respectively[1].

Product Specifications

CAS Number

[2957895-04-2]

UNSPSC

12352005

Target

PIN1; PROTACs

Related Pathways

PI3K/Akt/mTOR; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC(C(CC1)N2C(C3=CC=C(NCCCCCCCCCCCCNC(CCC(NCC(C)(CN(C4CCS(=O)(C4)=O)C(CCl)=O)C)=O)=O)C=C3C2=O)=O)=O

Molecular Formula

C40H59ClN6O9S

Molecular Weight

835.45

References & Citations

[1]Zhoubing, et al. Compound for degrading Pin1 protein in targeted ubiquitination, and pharmaceutical composition and application thereof. Patent CN116425733A.