P38α MAPK/CK1δ inhibitor-1
P38α MAPK/CK1δ inhibitor-1 (Compound 3) exhibits inhibitory activity against p38α MAPK and CK1δ with IC50s of 0.185 µM and 0.089 µM[1].
Product Specifications
CAS Number
[1572047-84-7]
UNSPSC
12352005
Target
Casein Kinase; p38 MAPK
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=CC(N2N=NC(C3=NC(C4=CC=C(F)C=C4)=C(N3C)C5=CC=NC=C5)=C2)=C1)O
Molecular Formula
C24H17FN6O2
Molecular Weight
440.43
References & Citations
[1]Seerden JP, et al., Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38α MAPK, CK1δ and JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24 (15) :3412-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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