P38α inhibitor 8
P38α inhibitor 8 (Compound 1) exhibits inhibitory activity against p38α MAPK and CK1δ with IC50 of 0.21 µM and 0.202 µM[1]>.
Product Specifications
CAS Number
[1572047-63-2]
UNSPSC
12352005
Target
Casein Kinase; p38 MAPK
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
FC1=CC=C(C2=C(C3=CC=NC=C3)N(C)C(C4=CN=NN4)=N2)C=C1
Molecular Formula
C17H13FN6
Molecular Weight
320.32
References & Citations
[1]Seerden JP, et al., Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38α MAPK, CK1δ and JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24 (15) :3412-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1; p38α
Curated Selection
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