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P38α inhibitor 8

P38α inhibitor 8 (Compound 1) exhibits inhibitory activity against p38α MAPK and CK1δ with IC50 of 0.21 µM and 0.202 µM[1]>.

Product Specifications

CAS Number

1572047-63-2

UNSPSC

12352005

Target

Casein Kinase; p38 MAPK

Related Pathways

Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Smiles

FC1=CC=C(C2=C(C3=CC=NC=C3)N(C)C(C4=CN=NN4)=N2)C=C1

Molecular Formula

C17H13FN6

Molecular Weight

320.32

References & Citations

[1]Seerden JP, et al., Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38α MAPK, CK1δ and JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24 (15) :3412-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CK1; p38α

Frequently Asked Questions

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