P38 Kinase inhibitor 8
P38 Kinase inhibitor 8 (Compound CCLXXVIII) is the orally active inhibitor for p38β and JNK2α2 with IC50s of 6.3 nM and 53.6 nM. p38 Kinase inhibitor 8 exhibits anti-inflammatory effect in rats collagen-induced arthritis models[1].
Product Specifications
CAS Number
[815595-25-6]
UNSPSC
12352005
Target
JNK; p38 MAPK
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(C)N1CCC(CC1)NC2=NC(C3=C(C4=CC=C(C=C4)F)N=C5OC=CN53)=CC=N2
Molecular Formula
C22H21FN6O2
Molecular Weight
420.44
References & Citations
[1]Ashwell M, et al., Imidazothiazoles and imidazoxazole derivatives as inhibitors of p38. WO2004110990
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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