CK1δ-IN-9
CK1δ-IN-9 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1δ with IC50 of 1.4 nM. CK1δ-IN-9 inhibits p38α and p38β with IC50 of 0.25 μM and 0.78 μM. CK1δ-IN-9 exhibits pharmacokinetic characteristics with a good oral bioavailability (70%) and a moderate clearance[1].
Product Specifications
CAS Number
3057263-82-5
UNSPSC
12352005
Target
Casein Kinase; p38 MAPK
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Others
Smiles
FC1=CC=C(C2=NN(C)C=C2C3=C4C=NNC4=NC=C3)C=C1
Molecular Formula
C16H12FN5
Molecular Weight
293.30
References & Citations
[1]McCarver S, et al., Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions. ACS Med Chem Lett. 2024 Mar 7;15 (4) :486-492.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1; p38α; p38β
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