CK1δ-IN-9

CK1δ-IN-9 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1δ with IC50 of 1.4 nM. CK1δ-IN-9 inhibits p38α and p38β with IC50 of 0.25 μM and 0.78 μM. CK1δ-IN-9 exhibits pharmacokinetic characteristics with a good oral bioavailability (70%) and a moderate clearance[1].

Product Specifications

CAS Number

[3057263-82-5]

UNSPSC

12352005

Target

Casein Kinase; p38 MAPK

Related Pathways

Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt

Field of Research

Others

Smiles

FC1=CC=C(C2=NN(C)C=C2C3=C4C=NNC4=NC=C3)C=C1

Molecular Formula

C16H12FN5

Molecular Weight

293.30

References & Citations

[1]McCarver S, et al., Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions. ACS Med Chem Lett. 2024 Mar 7;15 (4) :486-492.