Casein kinase 1δ-IN-29
Casein kinase 1δ-IN-29 (Compound 18) is the inhibitor for p38α and casein kinase 1 that inhibits p38α, CK1δ and CK1ε with IC50 of 0.041 µM, 0.005 µM and 0.447 µM, respectively. Casein kinase 1δ-IN-29 arrests cell cycle at subG1 phase, induces apoptosis in cell AC1-M88[1].
Product Specifications
CAS Number
1177418-39-1
UNSPSC
12352005
Target
Apoptosis; Casein Kinase; p38 MAPK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Smiles
CS(C1=NC(C2=CC=C(C=C2)F)=C(C3=CC=NC(NC(/C=C/C4=C(C=C(C=C4)OC)OC)=O)=C3)N1)=O
Molecular Formula
C26H23FN4O4S
Molecular Weight
506.55
References & Citations
[1]Peifer C, et al., 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. J Med Chem. 2009 Dec 10;52 (23) :7618-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1; p38α
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