Casein kinase 1δ-IN-27

Casein kinase 1δ-IN-27 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1α, CK1δ, CK1ε, and p38α with IC50s of 22, 16.5, 9.41 and 14.8 nM, respectively. Casein kinase 1δ-IN-27 inhibits the DUX4 expression with an IC50 of 10 nM[1].

Product Specifications

CAS Number

[1095706-65-2]

UNSPSC

12352005

Target

Casein Kinase; p38 MAPK

Related Pathways

Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt

Field of Research

Cancer

Smiles

FC1=CC=C(C2=C(C3=CC=NC=C3)N4N=C(N5CCNCC5)C=CC4=N2)C=C1

Molecular Formula

C21H19FN6

Molecular Weight

374.41

References & Citations

[1]Maeyer JD, et al. Casein kinase 1 inhibitors for use in the treatment of diseases related to dux4 expression such as muscular dystrophy and cancer. WO2020249717