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Casein kinase 1δ-IN-27

Casein kinase 1δ-IN-27 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1α, CK1δ, CK1ε, and p38α with IC50s of 22, 16.5, 9.41 and 14.8 nM, respectively. Casein kinase 1δ-IN-27 inhibits the DUX4 expression with an IC50 of 10 nM[1].

Product Specifications

CAS Number

1095706-65-2

UNSPSC

12352005

Target

Casein Kinase; p38 MAPK

Related Pathways

Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt

Field of Research

Cancer

Smiles

FC1=CC=C(C2=C(C3=CC=NC=C3)N4N=C(N5CCNCC5)C=CC4=N2)C=C1

Molecular Formula

C21H19FN6

Molecular Weight

374.41

References & Citations

[1]Maeyer JD, et al. Casein kinase 1 inhibitors for use in the treatment of diseases related to dux4 expression such as muscular dystrophy and cancer. WO2020249717

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CK1; p38α

Frequently Asked Questions

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