PRDX1-IN-3
PRDX1-IN-3 (compound 19-048) is a PRDX1 covalent inhibitor with anti-colorectal cancer activity. PRDX1-IN-3 can effectively inhibit the proliferation of colorectal cancer cells, and its antitumor effect on nude mice with colorectal cancer carrying PRDX1 gene knockout is significantly reduced. PRDX1-IN-3 also upregulates the downstream genes of the p53 signaling pathway to exert an anticancer effect[1].
Product Specifications
CAS Number
[2566976-46-1]
UNSPSC
12352211
Target
MDM-2/p53; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.52
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)NC(N[C@@H](C)C(OC)=O)=O)C)(CC[C@@]4(C2=CC=C5C4=CC(C(O)=C5C)=O)C)C
Molecular Formula
C33H46N2O5
Molecular Weight
550.73
References & Citations
[1]Xu H, et al. Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal Transduct Target Ther. 2023 Feb 3;8 (1) :51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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