EGFR-IN-145
EGFR-IN-145 (compound 7c) is an EGFR kinase inhibitor. At a concentration of 20 μM, EGFR-IN-145 has an inhibition rate of 52.7% on EGFR-wild type kinase[1].
Product Specifications
CAS Number
852407-49-9
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
FC(C=C1)=CC=C1CNC2=C3C(SC4=C3CCCC4)=NC=N2
Molecular Formula
C17H16FN3S
Molecular Weight
313.39
References & Citations
[1]Wu CH, et al. Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency. J Med Chem. 2010 Oct 28;53 (20) :7316-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
FAB62981JF669 0.1 mL
Rabbit Monoclonal MUC1 Antibody (2336A) [Janelia Fluor 669]
Sign In for Pricing
View Details 
P10359P 1000 Units/Pack
Printed with Looped cap Screw Cap Tube, Conical, PP, 2.0 mL, Sterile, with EPDM ring Cap, Purple, DNase/RNase free - 1000 un. - ABDOS
Sign In for Pricing
View Details