LNK01004
LNK01004 is a JAK inhibitor with strong inhibitory effects on JAK1 (IC50: 10 nM), JAK2 (IC50:TYK2 (IC50: 1.0 nM) . LNK01004 can simultaneously inhibit multiple cytokine-induced p-STAT signaling pathways. LNK01004 can be used in the research of diseases such as atopic dermatitis[1].
Product Specifications
CAS Number
2445500-24-1
UNSPSC
12352005
Target
JAK; STAT
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Others
Smiles
N#CCNC(C1=CC=C(C2=NC(NC3=CN(C4CC(C)(C)OC(C)(C4)C)N=C3)=NC=C2C)C=C1)=O
Molecular Formula
C26H31N7O2
Molecular Weight
473.57
References & Citations
[1]Gao YJ, et al. Crystal form of pyrazolyl-amino-pyrimidinyl derivative, and preparation method therefor and use thereof. WO2023151724A1. 2023-08-17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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