LNK01004

LNK01004 is a JAK inhibitor with strong inhibitory effects on JAK1 (IC50: 10 nM), JAK2 (IC50:TYK2 (IC50: 1.0 nM) . LNK01004 can simultaneously inhibit multiple cytokine-induced p-STAT signaling pathways. LNK01004 can be used in the research of diseases such as atopic dermatitis[1].

Product Specifications

CAS Number

[2445500-24-1]

UNSPSC

12352005

Target

JAK; STAT

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Others

Smiles

N#CCNC(C1=CC=C(C2=NC(NC3=CN(C4CC(C)(C)OC(C)(C4)C)N=C3)=NC=C2C)C=C1)=O

Molecular Formula

C26H31N7O2

Molecular Weight

473.57

References & Citations

[1]Gao YJ, et al. Crystal form of pyrazolyl-amino-pyrimidinyl derivative, and preparation method therefor and use thereof. WO2023151724A1. 2023-08-17.