1-Acetyl-DHAP
1-Acetyl-DHA (Compound 7) is a substrate of the phosphotriesterase homology protein (PHP) and can be hydrolyzed by PHP with a kcat/km value of 100 M-1s-1. The level of 1-Acetyl-DHA is regulated by mTORC1 and is negatively correlated with the nuclear acetate level. 1-Acetyl-DHA plays an important role in cellular metabolism and the regulation of histone acetylation[1][2].
Product Specifications
CAS Number
2267338-53-2
UNSPSC
12352211
Target
MTOR
Related Pathways
PI3K/Akt/mTOR
Field of Research
Others
Smiles
O=C(C)OCC(COP(O)(O)=O)=O
Molecular Formula
C5H9O7P
Molecular Weight
212.09
References & Citations
[1]Nemmara VV, et al. Substrate Profile of the Phosphotriesterase Homology Protein from Escherichia coli. Biochemistry. 2018 Oct 30;57 (43) :6219-6227.|[2]Zhang JJ, et al. Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation. Nat Metab. 2021 Jun;3 (6) :859-875.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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