1-Acetyl-DHAP

1-Acetyl-DHA (Compound 7) is a substrate of the phosphotriesterase homology protein (PHP) and can be hydrolyzed by PHP with a kcat/km value of 100 M-1s-1. The level of 1-Acetyl-DHA is regulated by mTORC1 and is negatively correlated with the nuclear acetate level. 1-Acetyl-DHA plays an important role in cellular metabolism and the regulation of histone acetylation[1][2].

Product Specifications

CAS Number

[2267338-53-2]

UNSPSC

12352211

Target

MTOR

Related Pathways

PI3K/Akt/mTOR

Field of Research

Others

Smiles

O=C(C)OCC(COP(O)(O)=O)=O

Molecular Formula

C5H9O7P

Molecular Weight

212.09

References & Citations

[1]Nemmara VV, et al. Substrate Profile of the Phosphotriesterase Homology Protein from Escherichia coli. Biochemistry. 2018 Oct 30;57 (43) :6219-6227.|[2]Zhang JJ, et al. Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation. Nat Metab. 2021 Jun;3 (6) :859-875.