TG-100435
TG-100435 is a multitargeted, orally active protein tyrosine kinase inhibitor, with Ki of 13 to 64 nM for Src, Lyn, Abl, Yes, Lck, and EphB4. TG-100435 plays an important role in cancer research[1].
Product Specifications
CAS Number
867330-68-5
UNSPSC
12352005
Target
Bcr-Abl; Ephrin Receptor; Src
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
ClC1=C(C2=CC3=C(C(C)=C2)N=C(NC4=CC=C(C=C4)OCCN5CCCC5)N=N3)C(Cl)=CC=C1
Molecular Formula
C26H25Cl2N5O
Molecular Weight
494.42
References & Citations
[1]Steven X Hu, et al. Metabolism and pharmacokinetics of a novel Src kinase inhibitor TG100435 ([7- (2,6-dichloro-phenyl) -5-methyl-benzo[1,2,4]triazin-3-yl]-[4- (2-pyrrolidin-1-yl-ethoxy) -phenyl]-amine) and its active N-oxide metabolite TG100855 ([7- (2,6-dichloro-phenyl) -5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2- (1-oxy-pyrrolidin-1-yl) -ethoxy]-phenyl}-amine) . Comparative Study Drug Metab Dispos. 2007 Jun;35 (6) :929-36.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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