NB-3
NB-3 is a nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 inhibitor. NB-3 intercepts NAD hydrolysis and undergoes covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR) . The resulting small-molecule ADPR adducts are highly potent and confer compelling neuroprotection in neurological injury[1].
Product Specifications
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Field of Research
Neurological Disease
Smiles
O=C(NCC(F)(F)F)N(C)[C@H](C1=CC=NC=C1)C
Molecular Formula
C11H14F3N3O
Molecular Weight
261.24
References & Citations
[1]Bratkowski M, et al. Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease. Neuron. 2022 Nov 16;110 (22) :3711-3726.e16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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