NB-3

NB-3 is a nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 inhibitor. NB-3 intercepts NAD hydrolysis and undergoes covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR) . The resulting small-molecule ADPR adducts are highly potent and confer compelling neuroprotection in neurological injury[1].

Product Specifications

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation

Field of Research

Neurological Disease

Smiles

O=C(NCC(F)(F)F)N(C)[C@H](C1=CC=NC=C1)C

Molecular Formula

C11H14F3N3O

Molecular Weight

261.24

References & Citations

[1]Bratkowski M, et al. Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease. Neuron. 2022 Nov 16;110 (22) :3711-3726.e16.