Chlorzolamide
Chlorzolamide (CL 13580) is a carbonic anhydrase (CA) inhibitor. Chlorzolamide has an effect on the skeletal muscle of rats, which can reduce the tetanic contraction force of soleus and extensor digitorum longus and prolong the relaxation time and peak time of muscle contraction. In addition, Chlorzolamide inhibits tumor cell proliferation and has antitumor activity[1][2].
Product Specifications
CAS Number
[5541-92-4]
Product Name Alternative
CL 13580
UNSPSC
12352005
Target
Carbonic Anhydrase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=S(N)(C1=NN=C(C2=C(Cl)C=CC=C2)S1)=O
Molecular Formula
C8H6ClN3O2S2
Molecular Weight
275.74
References & Citations
[1]Genis C, et al. Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties. Biochemistry. 2009 Feb 17;48 (6) :1322-31.|[2]Geers C, et al. Effects of carbonic anhydrase inhibitors on contraction, intracellular pH and energy-rich phosphates of rat skeletal muscle. J Physiol. 1990 Apr;423:279-97.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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