AB8939
AB8939 is an effective small moleculeMicrotubule/Tubulin polymerization inhibitor with anti-tumor activity (it inhibits tumor cell proliferation with an IC50 of less than 10 nM) . AB8939 can effectively evade resistance mechanisms mediated by things like P-glycoprotein and myeloperoxidase. AB8939 can induce G2/M phase cell cycle arrest and apoptosis in cells[1].
Product Specifications
CAS Number
[1974336-09-8]
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
O=C1NCCN1C2=CC=C(C3=CN=C(NC4=CC(COCC)=CC=C4C)O3)C=C2
Molecular Formula
C22H24N4O3
Molecular Weight
392.45
References & Citations
[1]Martine Humbert PhD, et al. Anticancer Activity of a Highly Potent Small Molecule Tubulin Polymerization Inhibitor, AB8939. Blood. Volume 134, Supplement 1, 13 November 2019, Page 2075.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Curated Selection
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