DK2403
DK2403 (compound 25) is a MAP2K7 inhibitor (IC50= 0.01 μM) . DK2403 can effectively inhibit MAP2K7 without significantly disrupting the larger kinase group and can be used to study childhood T-cell acute lymphoblastic leukemia[1].
Product Specifications
CAS Number
2902651-64-1
UNSPSC
12352005
Target
P38 MAPK
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.24
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(CCl)NC1=CC(OC2=NC=NC(NCC3=CC=CC=C3)=C2)=CC=C1
Molecular Formula
C19H17ClN4O2
Molecular Weight
368.82
References & Citations
[1]Kim DR, et al. Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors. ACS Med Chem Lett. 2023 Apr 17;14 (5) :606-613.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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