UniPR500

UniPR500, a UniPR129 derivative, is a competitive EphA2 receptor antagonist with a Ki of 0.78 μM. UniPR500 dose-dependently reduces binding of biotinylated ephrin-A1 to EphA2 with an IC50 value of 1.1 μM[1].

Product Specifications

CAS Number

[2085767-98-0]

UNSPSC

12352211

Target

Ephrin Receptor

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(N[C@H](CC(O)=O)CC3=CNC4=CC=CC=C34)=O)([H])[C@@]5([H])[C@@](CC1)([H])[C@@]6([C@](C/C(CC6)=N/O)([H])CC5)C

Molecular Formula

C36H51N3O4

Molecular Weight

589.81

References & Citations

[1]Ferlenghi F, et al. Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph-Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice. Pharmaceuticals (Basel) . 2021 Dec 28;15 (1) :41.