NSC 357754 (dihydrochloride)
NSC 357754 dihydrochloride is an inhibitor of Claudin. NSC 357754 dihydrochloride can increase the transepithelial electrical resistance of cells and reduce the permeability of specific cations. NSC 357754 dihydrochloride can be used in the research of intestinal diseases mediated by Claudin-2 and/or Claudin-15[1].
Product Specifications
UNSPSC
12352005
Target
Claudin
Related Pathways
Cytoskeleton
Field of Research
Metabolic Disease
Purity
98.01
Solubility
H2O : < 0.1 mg/mL (ultrasonic)
Smiles
N=C(C1=CC2=C(OC(/C=C/C3=CC=C(C4=CC5=CC(C(N)=N)=CC=C5O4)C=C3)=C2)C=C1)N.Cl.Cl
Molecular Formula
C26H22Cl2N4O2
Molecular Weight
493.38
References & Citations
[1]Christopher R, et al. Claudin inhibitors and methods of use thereof. WO2023102209A1. 2023-06-08.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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