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NSC 357754 (dihydrochloride)

NSC 357754 dihydrochloride is an inhibitor of Claudin. NSC 357754 dihydrochloride can increase the transepithelial electrical resistance of cells and reduce the permeability of specific cations. NSC 357754 dihydrochloride can be used in the research of intestinal diseases mediated by Claudin-2 and/or Claudin-15[1].

Product Specifications

UNSPSC

12352005

Target

Claudin

Related Pathways

Cytoskeleton

Field of Research

Metabolic Disease

Purity

98.01

Solubility

H2O : < 0.1 mg/mL (ultrasonic)

Smiles

N=C(C1=CC2=C(OC(/C=C/C3=CC=C(C4=CC5=CC(C(N)=N)=CC=C5O4)C=C3)=C2)C=C1)N.Cl.Cl

Molecular Formula

C26H22Cl2N4O2

Molecular Weight

493.38

References & Citations

[1]Christopher R, et al. Claudin inhibitors and methods of use thereof. WO2023102209A1. 2023-06-08.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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