F1-RIBOTAC

F1-RIBOTAC is a ribonuclease-targeting chimeras (RIBOTACs) . F1-RIBOTAC decreases QSOX1-a mRNA expression level in an RNase L-dependent manner. F1-RIBOTAC can be used for the research of cancer[1]. (Pink: RNA ligand (HY-168460) ; Black: linker (HY-W008005) ; Blue: RNase L ligand (HY-168452) )

Product Specifications

CAS Number

[3019907-96-8]

UNSPSC

12352005

Target

PROTACs

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

OC(C=C(C=C1)/C=C2C(C(C(OCC)=O)=C(S/2)NC3=CC=CC=C3)=O)=C1OCCOCCOCCOCCNC(CCC(N([C@@H]4C5=CC=CC=C5[C@H](C6=CC(Cl)=C(C=C6)Cl)CC4)C)=O)=O

Molecular Formula

C49H53Cl2N3O10S

Molecular Weight

946.93

References & Citations

[1]Tong Y, et al. Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA. J Am Chem Soc. 2022 Jul 6;144 (26) :11620-11625.