HDAC6 ligand-2
HDAC6 ligand-2 (Compound 15) is the ligand for HDAC6 that can be used for synthesis of PROTAC HDAC6 degrader 2 (HY-171139) [1].
Product Specifications
UNSPSC
12352005
Target
HDAC; Ligands for Target Protein for PROTAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Field of Research
Cancer
Purity
98.70
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(C1=NN=C(C2=CN=C(NCC3=CC(CNC(OCC4=CC=CC=C4)=O)=CC=C3)N=C2)O1)F
Molecular Formula
C23H20F2N6O3
Molecular Weight
466.44
References & Citations
[1]Keuler T, et al., Development of the first non-hydroxamate selective HDAC6 degraders. Chem Commun (Camb) . 2022 Oct 4;58 (79) :11087-11090.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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