PROTAC HDAC6 degrader 3
PROTAC HDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader for HDAC6 with an IC50 of 686 nM and a DC50 of 171 nM. PROTAC HDAC6 degrader 3 promotes the acetylation of α-tubulin[1]. (Pink: ligand for target protein (HY-171141) ; Blue: ligand for E3 ligase VHL (HY-150803) )
Product Specifications
UNSPSC
12352005
Target
HDAC; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Field of Research
Cancer
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C2=CC=C([C@H](C)NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(COCCOCCOCC(NCC4=CC=CC(CNC5=NC=C(C6=NN=C(C(F)F)O6)C=N5)=C4)=O)=O)C(C)(C)C)=O)=O)C=C2)SC=N1
Molecular Formula
C46H56F2N10O9S
Molecular Weight
963.06
References & Citations
[1]Keuler T, et al., Development of the first non-hydroxamate selective HDAC6 degraders. Chem Commun (Camb) . 2022 Oct 4;58 (79) :11087-11090.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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