PROTAC HDAC6 degrader 2
PROTAC HDAC6 degrader 2 (Compound 1) is a HDAC6 PROTAC degrader, with IC50 of 0.643 μM. PROTAC HDAC6 degrader 2 promotes ubiquitination and degradation of HDAC6. PROTAC HDAC6 degrader 2 can be used for the research of haematological and solid cancers (Pink: HDAC6 ligand ; Blue: E3 ligase CRBN ligand (HY-10984) ).
Product Specifications
UNSPSC
12352005
Target
HDAC; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Field of Research
Cancer
Concentration
10mM
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C1=NN=C(C2=CN=C(NCC3=CC(CNC(COCCOCCNC4=CC=CC5=C4C(N(C6CCC(NC6=O)=O)C5=O)=O)=O)=CC=C3)N=C2)O1)F
Molecular Formula
C34H33F2N9O8
Molecular Weight
733.68
References & Citations
[1]Keuler T, et al. Development of the first non-hydroxamate selective HDAC6 degraders. Chem Commun (Camb) . 2022 Oct 4;58 (79) :11087-11090.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6
Available Sizes
Frequently Asked Questions
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