Maytansine derivative M24

Maytansine derivative M24 is an ADC Drug-Linker Conjugates for ADC that can be used to synthesize ADC REGN5093-M114[1].

Product Specifications

CAS Number

[2226467-81-6]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Cancer

Smiles

C[C@]12[C@H]([C@@H]([C@@H]3C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCN(C)C(OCC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@@H](NC(CCCCC(O)=O)=O)C(C)C)=O)=O)C=C5)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)O1

Molecular Formula

C61H86ClN9O18

Molecular Weight

1268.84

References & Citations

[1]Drilon A, et al. EP10. 01-03 A Phase 1/2 Study of REGN5093-M114, a METxMET Antibody-Drug Conjugate, in Patients with MET-Overexpressing NSCLC. Journal of Thoracic Oncology, 2023, 18 (11) : S602-S603.