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KSP-1007

KSP-1007 is a bicyclic boronate-based broad-spectrum β-lactamase inhibitor. KSP-1007 can effectively inhibit class A, B, C and D β-lactamases, including serine-type, metallo-type (such as NDM, VIM, IMP) and Acinetobacter baumannii OXA-type enzymes. KSP-1007 can enhance the antibacterial activity of Meropenem , reduce its MIC value, and be effective against carbapenemase-producing Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa. KSP-1007 can be used for the research of bacterial infection[1].

Product Specifications

CAS Number

2380240-20-8

UNSPSC

12352005

Target

Bacterial; Beta-lactamase

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

OC(C1=C2C(CCB(O2)O)=CC=C1OC3CN(C3)C([C@@H](C4=CN=CN4)N)=O)=O

Molecular Formula

C17H19BN4O6

Molecular Weight

386.17

References & Citations

[1]Takemoto K, et al. In vitro and in vivo activities of KSP-1007, a broad-spectrum inhibitor of serine- and metallo-β-lactamases, in combination with meropenem against carbapenem-resistant Gram-negative bacteria. Antimicrob Agents Chemother. 2024 Jun 5;68 (6) :e0160223.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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