PAR2 modulator-1
PAR2 modulator-1 (Compound C781) is a protease activated receptor type 2 (PAR2) antagonist. PAR2 modulator-1 can specifically inhibit the PAR2-dependent MAPK signaling pathway with an IC50 value of 8.5 μM. PAR2 modulator-1 can block the pain response triggered by PAR2 agonists. PAR2 modulator-1 can be used for the researches of inflammation, immunology and neurological disease, such as chronic pain and asthma[1].
Product Specifications
CAS Number
[2378159-28-3]
UNSPSC
12352005
Target
P38 MAPK; Protease Activated Receptor (PAR)
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease; Inflammation/Immunology
Smiles
O=C(C1=CC=CO1)N2C3([H])N(C([C@@H](C2)NC(CC(C)C)=O)=O)[C@@H](C(N(C3)CC4CCNCC4)=O)CC(C)C
Molecular Formula
C27H41N5O5
Molecular Weight
515.64
References & Citations
[1]Scott A. BOITANO, et al. Small molecule modulators of par2 and uses thereof. WO2019199800A1. 2020-10-09
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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