Glucocorticoid receptor agonist-6

Glucocorticoid receptor agonist-6 (Compound A) is a Glucocorticoid receptor (GR) agonist. Glucocorticoid receptor agonist-6 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[2117643-80-6]

UNSPSC

12352128

Target

ADC Payload; Glucocorticoid Receptor

Related Pathways

Antibody-drug Conjugate/ADC Related; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

O=P(O)(O)CCCCCCCCCCSC([C@@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@H](C2)O)([C@@]4(C([C@H](C3)F)=CC(C=C4)=O)C)F)([H])C[C@H]1C)C)OC(CC)=O)=O

Molecular Formula

C34H51F2O8PS

Molecular Weight

688.80

References & Citations

[1]Brandish PE, et al. Development of Anti-CD74 Antibody-Drug Conjugates to Target Glucocorticoids to Immune Cells. Bioconjug Chem. 2018 Jul 18;29 (7) :2357-2369.