FFA2 agonist-1
FFA2 agonist-1 (Compound 4) is the agonist for Free fatty acid receptor 2 (FFA2/GPR43) with an EC50 of 81 nM. FFA2 agonist-1 exhibits activity in β-arrestin-2 recruitment assay and cAMP inhibition assay with EC50 of 1.2 μM and 0.53 μM. FFA2 agonist-1 leads to appetite regulating peptide YY (PYY) mucosal responses, inhibits the fat accumulation, intestinal functions and food intake, and can be used for obesity research[1].
Product Specifications
CAS Number
1312799-06-6
UNSPSC
12352005
Target
Free Fatty Acid Receptor
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
O=C(C1=CC=C(C2=C(C=CC=C2)OC)C=C1)N3[C@@H](C4=C(C=CC=C4)Cl)CC[C@H]3C(O)=O
Molecular Formula
C25H22ClNO4
Molecular Weight
435.90
References & Citations
[1]Hansen AH, et al., Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8;61 (21) :9534-9550.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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