FFA2 agonist-1

FFA2 agonist-1 (Compound 4) is the agonist for Free fatty acid receptor 2 (FFA2/GPR43) with an EC50 of 81 nM. FFA2 agonist-1 exhibits activity in β-arrestin-2 recruitment assay and cAMP inhibition assay with EC50 of 1.2 μM and 0.53 μM. FFA2 agonist-1 leads to appetite regulating peptide YY (PYY) mucosal responses, inhibits the fat accumulation, intestinal functions and food intake, and can be used for obesity research[1].

Product Specifications

CAS Number

[1312799-06-6]

UNSPSC

12352005

Target

Free Fatty Acid Receptor

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

O=C(C1=CC=C(C2=C(C=CC=C2)OC)C=C1)N3[C@@H](C4=C(C=CC=C4)Cl)CC[C@H]3C(O)=O

Molecular Formula

C25H22ClNO4

Molecular Weight

435.90

References & Citations

[1]Hansen AH, et al., Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8;61 (21) :9534-9550.