Mc-Pro-PAB-MMAE
Mc-Pro-PAB-MMAE is a Drug-Linker Conjugate for ADC. Mc-Pro-PAB-MMAE consists of Monomethyl auristatin E and a linker. Mc-Pro-PAB-MMAE can be used for synthesis of ADCs[1][2].
Product Specifications
CAS Number
2766450-03-5
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.16
Solubility
DMSO : 100 mg/mL
Smiles
O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H]4N(CCC4)C(CNC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O
Molecular Formula
C64H95N9O14
Molecular Weight
1214.49
References & Citations
[1]Ilaria BIANCOFIORE, et al. Fibroblast activation protein ligands for targeted delivery applications. Patent, WO2021160825, 2021-08-19.|[2]Bocci M, et al. In vivo activation of FAP-cleavable small molecule-drug conjugates for the targeted delivery of camptothecins and tubulin poisons to the tumor microenvironment[J]. Journal of Controlled Release, 2024, 367: 779-790.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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