PTP1B/TC-PTP IN-1
PTP1B/TC-PTP IN-1 is a PTP1B and TC-PTP dual inhibitor. PTP1B/TC-PTP IN-1 can be used as a target protein ligand for the synthesis of DU-14 (PTP1B/TC-PTP PROTAC) (HY-164864) [1].
Product Specifications
CAS Number
[3053414-48-2]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=P(O)(O)C(F)(F)C(C=C1)=CC=C1C[C@H](NC([C@@H](NC(CC2=CC(OC)=C(C=C2)O)=O)CC3=CC=CC=C3)=O)C(N[C@@H](CCCCNC(C4=CC(Br)=C(C=C4)C)=O)C(O)=O)=O
Molecular Formula
C42H46BrF2N4O11P
Molecular Weight
931.71
References & Citations
[1]Dong J, et al. Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy. Angew Chem Int Ed Engl. 2023 May 22;62 (22) :e202303818.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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