Antitumor agent-196

Antitumor agent-196 (Compound 6a (β, β, β) ) is an artemisinin-based oligomer with anticancer activity, showing an IC50 of 90 nM against MCF-7 breast cancer cells. Antitumor agent-196 promotes Apoptosis by regulating the Bax-caspase 3 signaling pathway, and induces Ferroptosis through the modulation of key signaling molecules, including GPX4. Antitumor agent-196 holds promising potential for further research in the field of cancer therapy[1].

Product Specifications

CAS Number

[2705841-17-2]

UNSPSC

12352005

Target

Apoptosis; Caspase; Ferroptosis

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

C[C@@H]1[C@@]2([H])[C@]34[C@@](O[C@@H]1OCCN(CCO[C@H]5O[C@@]6([H])[C@]78[C@](CC[C@H]([C@]7([H])CC[C@](O6)(OO8)C)C)([H])[C@H]5C)CCO[C@H]9O[C@@]%10([H])[C@]%11%12[C@](CC[C@H]([C@]%11([H])CC[C@](O%10)(OO%12)C)C)([H])[C@H]9C)([H])O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C

Molecular Formula

C51H81NO15

Molecular Weight

948.19

References & Citations

[1]Jiang B, et al. Anti-tumor effects of artemisinin-based oligomers: From monomer to trimer as a novel drug-enhancing strategy. Eur J Med Chem. 2025 Apr 5;287:117313.