ATG16L1 stabilizer-1
ATG16L1 stabilizer-1 (compound A3B) is an FKBP12-independent ATG16L1 stabilizer that promotes cellular Autophagy. ATG16L1 stabilizer-1 inhibits ATG16L1 with an EC50 of 12.1 μM in the presence or absence of FKBP12. ATG16L1 stabilizer-1 alone induces GFP-LC3 puncta formation to a small extent with an EC50 of 12.0 μM[1].
Product Specifications
UNSPSC
12352005
Target
Autophagy
Related Pathways
Autophagy
Field of Research
Inflammation/Immunology
Smiles
O=C(C(C(C)(C)CC)=O)N1CCCC[C@@]1([H])C(N[C@@](CCC2=CC=C(OC)C=C2)([H])C(N3[C@@H]4C[C@H](NC5=NC(N6CCN7C(C6)=NC=N7)=NC(NCCC8=C(C)N=C(N)S8)=N5)C[C@H]3CC4)=O)=O
Molecular Formula
C45H62N14O5S
Molecular Weight
911.13
References & Citations
[1]Tan ZY, et al. Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator. Cell Chem Biol. 2024 Dec 30:S2451-9456 (24) 00491-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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