CypA ligand-1
CypA ligand-1 is the ligand for CypA that can be used as target protein ligand for synthesis of PROTAC degrader PROTAC CG167 (HY-173009) [1].
Product Specifications
UNSPSC
12352005
Target
Cyclophilin; Ligands for Target Protein for PROTAC
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Cancer
Smiles
[O-][N+](C(C=C1)=CC=C1C[C@H](NC(C/C=C/2)=O)C(N[C@@H](C)C(N(CCC3)N[C@@H]3C(O[C@@H](C4=CC=C5C=CC2=CC5=N4)CCCC#C)=O)=O)=O)=O
Molecular Formula
C36H38N6O7
Molecular Weight
666.72
References & Citations
[1]Newton LS, et al., Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV. Nat Commun. 2025 Feb 10;16 (1) :1484.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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