PROTAC ROR1 degrader-1
PROTAC ROR1 degrader-1 (Compound 11d) is a PROTAC degrader for pseudokinase ROR1 that degrades ROR1 in NSCLC cells with a DC50s of 40-80 nM. PROTAC ROR1 degrader-1 causes the cleavage of PARP and induces apoptosis in NCI-H23[1]. (Pink: ligand for target protein ROR1 ligand-1 ; Black: linker (HY-W014787) ; Blue: ligand for VHL E3 ligase (S, R, S) -AHPC (HY-125845) )
Product Specifications
UNSPSC
12352005
Target
Apoptosis; PROTACs; ROR
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
Molecular Formula
C55H74BrN11O5S
Molecular Weight
1081.22
References & Citations
[1]Li J, et al., Discovery of the first potent ROR1 degrader for the treatment of non-small cell lung cancer. Eur J Med Chem. 2025 Mar 15;286:117325.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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