PROTAC ROR1 degrader-1

PROTAC ROR1 degrader-1 (Compound 11d) is a PROTAC degrader for pseudokinase ROR1 that degrades ROR1 in NSCLC cells with a DC50s of 40-80 nM. PROTAC ROR1 degrader-1 causes the cleavage of PARP and induces apoptosis in NCI-H23[1]. (Pink: ligand for target protein ROR1 ligand-1 (HY-170996) ; Black: linker (HY-W014787) ; Blue: ligand for VHL E3 ligase (S, R, S) -AHPC (HY-125845) )