I2-IRs ligand-1
I2-IRs ligand-1 (Compound 12d) is an orally active and BBB-penetrable compound. I2-IRs ligand-1 has a high affinity for imidazoline I2 receptors (I2-IRs) (pKi: 9.98) . I2-IRs ligand-1 can improve cognitive impairment in senescent mice and exhibits analgesic, anti-inflammatory, and neuroprotective activities. I2-IRs ligand-1 can be used for the research of Alzheimer's disease and related pain disorders[1].
Product Specifications
UNSPSC
12352005
Target
Imidazoline Receptor
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C([C@H]1[C@](C2=CC=CC=C2)(P(OCC)(OCC)=O)N=CC1)NC3=CC=C(F)C(Cl)=C3
Molecular Formula
C21H23ClFN2O4P
Molecular Weight
452.84
References & Citations
[1]Bagán A, et al. Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2H-pyrrol-2-yl) phosphonates as Imidazoline I2 Receptor Ligands with Anti-Alzheimer and Analgesic Properties. J Med Chem. 2025 Feb 13;68 (3) :2551-2573.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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