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Antimicrobial agent-39

Antimicrobial agent-39 (Compound 8i) is an antibiotic that targets 50S ribosomal subunit and inhibits bacterial protein synthesis. Antimicrobial agent-39 disrupts bacterial cell membranes, leads to leakage of cell contents, thereby exhibiting board-spectrum actibacterial activity. Antimicrobial agent-39 targets organic cation transporters (OCTs), accumulates in infected kidneys, thereby ameliorating pyelonephritis in mouse models[1].

Product Specifications

UNSPSC

12352005

Target

Antibiotic; Bacterial

Related Pathways

Anti-infection

Field of Research

Infection; Inflammation/Immunology

Smiles

O=C1[C@]2([H])[C@@]([C@@H](C)[C@H](O)[C@@](C=C)(C)C[C@@H](OC(CSC3=NC(C=C[N+](CC4=CC=C(C)C=C4)=C5)=C5N3)=O)[C@@]26C)(CC[C@H]6C)CC1.[Br-]

Molecular Formula

C36H46BrN3O4S

Molecular Weight

696.74

References & Citations

[1]Tian L, et al., Kidney Targeting Smart Antibiotic Discovery: Multimechanism Pleuromutilins for Pyelonephritis Therapy. J Med Chem. 2025 Feb 13;68 (3) :3335-3355.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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