C12-rrw-NH2

C12-rrw-NH2 (Compound Lip7) is an antibacterial agent against gram-positive bacteria, especially against Methicillin (HY-121544) -resistant Staphylococcus aureus (MRSA) . C12-rrw-NH2 induces bacterial death via depolarizing the bacterial cytoplasmic membrane, disrupting the integrity of the bacterial membrane, leading to leakage of nucleic acid and protein and promoting the generation of Reactive Oxygen Species. C12-rrw-NH2 is potential to be used for research of developing high-stability antimicrobial peptides[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection

Smiles

CCCCCCCCCCCC(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CC1=CNC2=C1C=CC=C2)C(O)=O)=O)=O)=O

Molecular Formula

C35H58N10O5

Molecular Weight

698.90

References & Citations

[1]Zou J, et al. Ultra-short lipopeptides containing d-amino acid exhibiting excellent stability and antibacterial activity against gram-positive bacteria. Eur J Med Chem. 2025 Apr 5;287:117341.