BRD4 degrader-5
BRD4 degrader-5 (Compound 23) is a hydrophobic tag (HyTag) -based protein degrader for BRD4 (DC50 = 24.7 μM) through ER stress and autophagy-lysosome pathway. BRD4 degrader-5 inhibits the proliferation of cancer cell 4T1 with an IC50 of 20.6 μM[1].
Product Specifications
UNSPSC
12352005
Target
AUTACs; Autophagy; Epigenetic Reader Domain
Related Pathways
Autophagy; Epigenetics; PROTAC
Field of Research
Cancer
Smiles
CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[C@@H](CC(N3CCN(CC(NC4(C5)C[C@@H]6C[C@@H](C[C@H]5C6)C4)=O)CC3)=O)C7=NN=C(C)N78)=C8S1
Molecular Formula
C35H42ClN7O2S
Molecular Weight
660.27
References & Citations
[1]Balestrero FC, et al., Versatile One-Pot Synthesis of Hydrophobic Tags by Multicomponent Reactions. ACS Omega. 2025 Jan 30;10 (5) :4745-4753.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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