BuChE-IN-16
BuChE-IN-16 (Compound 6a) is an orally active, BBB-permeable, and selective BuChE inhibitor with an IC50 of 0.33 μM. BuChE-IN-16 has anti-inflammatory and neuroprotective effects. BuChE-IN-16 can improve the cognitive function of zebrafish with Alzheimer's disease (AD) and alleviate memory impairment in mice induced by Scopolamine. BuChE-IN-16 can be used for the research of AD[1].
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N1CCCCC1)C2=CC(OC(N(C)CC)=O)=CC=C2
Molecular Formula
C16H22N2O3
Molecular Weight
290.36
References & Citations
[1]Li Y, et al. Development of novel rivastigmine derivatives as selective BuChE inhibitors for the treatment of AD. Bioorg Chem. 2025 Feb 6;157:108245.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BChE
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