SDH-IN-20

SDH-IN-20 (compound A19) is an antifungal agent. SDH-IN-20 against Verticillium dahlia, R. solani with EC50s of less than 3.0 μg/mL, 2.87 μg/mL. SDH-IN-20 exerts its highly antifungal effects by acting as an effective succinate dehydrogenase (SDH) inhibitor with an IC50 of 29.33 μM. SDH-IN-20 adversely impacts the integrity of cell membranes and mycelial morphologies of R. solani[1].

Product Specifications

UNSPSC

12352005

Target

Fungal

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

FC1=CC=CC=C1NNC(C2=CSC(C(C=C3)=CC=C3NC4=NC=NC5=CC=CC=C54)=N2)=O

Molecular Formula

C24H17FN6OS

Molecular Weight

456.49

References & Citations

[1]Yi M, et al. Design, synthesis, crystal structure, fungicidal activity, and mechanism of action of novel thiazole-based hydrazide derivatives containing the 4-aminoquinazoline moiety. Bioorg Chem. 2025 Mar;156:108237.