PARP/NAMPT-IN-1
PARP/NAMPT-IN-1 (Compound 13j) is a dual PARP/NAMPT inhibitor with IC50 values of 0.8 nM and 18 nM for PARP1 and NAMPT, respectively. PARP/NAMPT-IN-1 can inhibit the proliferation, migration and induce apoptosis of breast cancer cells. PARP/NAMPT-IN-1 can be used for the research of triple-negative breast cancer[1].
Product Specifications
CAS Number
2755825-45-5
UNSPSC
12352005
Target
Apoptosis; NAMPT; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(NCCCCCCN1CCN(C(C2=C(F)C=CC(CC3=NNC(C4=C3C=CC=C4)=O)=C2)=O)CC1)C5=CC6=NC=CN6C=C5
Molecular Formula
C34H36FN7O3
Molecular Weight
609.69
References & Citations
[1]Mao J, et al. Discovery of dual PARP/NAMPT inhibitors for the treatment of BRCA wild-type triple-negative breast cancer. Bioorg Med Chem Lett. 2025 Jan 30;120:130117.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PKSH030507 100 µg
Recombinant Human Frizzled-10/FZD10 Protein (His Tag)
Sign In for Pricing
View Details 