HIV-1 inhibitor-81

HIV-1 inhibitor-81 (Compound 14g) is an HIV-1 protease inhibitor with a Ki of 1.6 nM. HIV-1 inhibitor-81 exhibits certain antiviral activity, with an EC50 of 250 nM for HIV-1[1].

Product Specifications

UNSPSC

12352005

Target

HIV; HIV Protease

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

[H][C@@]12C[C@H](O3)CC[C@H](OC(N[C@H]([C@H](O)CN(CC(C)C)S(C4=CC=C(OC)C=C4)(=O)=O)CC5=CC=CC=C5)=O)[C@@]13[C@H](C)OC2

Molecular Formula

C32H44N2O8S

Molecular Weight

616.77

References & Citations

[1]Ghosh AK, et al. Potent HIV‑1 protease inhibitors containing oxabicyclo octanol-derived P2-ligands: Design, synthesis, and X‑ray structural studies of inhibitor-HIV-1 protease complexes. Bioorg Med Chem Lett. 2025 Jan 21;120:130109.