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Anticancer agent 264

Anticancer agent 264 (Compound 5w) is an anticancer agent that exhibits significant antiproliferative activity across tumor cell lines, with an IC50 range of 7.5-33.67 μM. Anticancer agent 264 significantly induces G2/M phase arrest in MDA-MB-231, MIA PaCa-2, and DU-145 cell lines. Anticancer agent 264 reduces the expression of key cell cycle proteins, including CDK1, CDK2, and Cyclin B1, in a dose-dependent manner, and shows strong binding affinity with inhibitor of differentiation (ID) proteins and DNA-binding proteins. Anticancer agent 264 can be used for research in the field of cancer-related diseases[1].

Product Specifications

UNSPSC

12352005

Target

CDK; DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

ClC1=C(NC(C2=NOC(CN3CCN(C4=C(C(F)=C(C(F)=C4F)F)F)CC3)=N2)=N1)C5=CC=C(C=C5)C

Molecular Formula

C23H18ClF5N6O

Molecular Weight

524.87

References & Citations

[1]Nagineni D, et al. Imidazole-1,2,4-oxadiazole-piperazine hybrids as potent anticancer agents: Synthesis, biological evaluation and molecular docking. Bioorg Chem. 2025 Mar;156:108208.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK1; CDK2

Curated Selection

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